Eddie Murphy Dr. John Dolittle Ossie Davis Archer Dolittle Oliver Platt Dr. Mark Weller Peter Boyle Calloway Richard Schiff Dr. Gene Reiss Kristen Wilson Lisa Jeffrey Tambor Dr. Fish Kyla Pratt Maya Raven-Symoné Charisse Steven Gilborn Dr. Litvack Erik Dellums Jeremy June Christopher Diane Cherie Franklin Mrs. Parkus Norm Macdonald Lucky (voice) Chris Rock Rodney (voice) Albert Brooks Tiger (voice) Jenna Elfman Owl (Voice) Reni Santoni Rat #1 (Voice) John Leguizamo Rat #2 (Voice) Julie Kavner Female Pigeon (voice) Garry Shandling Male Pigeon (voice) Ellen DeGeneres Prologue Dog (voice) Paul Reubens Raccoon (voice) Eddie Frierson Skunk (voice) Phil Proctor Drunk Monkey (Voice) Gilbert Gottfried Compulsive Dog (Voice) Brian Doyle-Murray Old Beagle (voice) Douglas Shamburger Pound Dog (voice) Jeff Doucette Possum (voice) Archie Hahn Heavy Woman's Dog (voice) Tom Towles German Shepherd (voice) Royce D. Applegate 'I Love You' Dog (voice) Chad Einbinder Bettleheim the Cat (voice) Jonathan Lipnicki Baby Tiger (voice) Hamilton Camp Pig (voice) Kerrigan Mahan Penguin (voice) Mark Adair-Rios Intern Don Calfa Patient at Hammersmith Kellye Nakahara Beagle Woman Beth Grant Woman Yule Caise Vet's Assistant Charles Branklyn Security Guard Richard Penn Mr. Galvin Karl T. Wright Reporter Stan Sellers Cop #1 Ming Lo Cop #2 Paul Giamatti Blaine (uncredited) Benny Buettner Circus Clown (uncredited) Pruitt Taylor Vince Patient at Hammersmith (uncredited) Crystal the Monkey Drunk Monkey (uncredited)

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